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RaDR Mice: Fluorescence Detection of Mutant Cells
Homologous recombination is critical for repairing double strand breaks (DSBs), but it likely evolved primarily as amechanism for repairing broken replication forks. DNA replication forks can break...
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MicroColonyChip: Cell Survival Quantitation
We have recently developed the MicroColonyChip, a new cell survival platform that uses a novel metric: colony size (Cell Reports, 2019). The ‘gold standard’ for quantification of cytotoxicity is the...
View ArticleSynthesis-Dependent Strand Annealing (Homologous Recombination)
Animation published in DNA Repair: Helleday T, Lo J, van Gent DC, Engelward BP. DNA double-strand break repair: From mechanistic understanding to cancer treatment. DNA Repair. (14 Mar 2007)
View ArticleDouble-Strand Break Repair via Double Holliday Junctions (Szostak Model)
Animation published in DNA Repair: Helleday T, Lo J, van Gent DC, Engelward BP. DNA double-strand break repair: From mechanistic understanding to cancer treatment. DNA Repair. (14 Mar 2007)
View ArticleInappropriate One-Ended Double-Strand Break Repair via Non-Homologous End...
Animation published in DNA Repair: Helleday T, Lo J, van Gent DC, Engelward BP. DNA double-strand break repair: From mechanistic understanding to cancer treatment. DNA Repair. (14 Mar 2007)
View ArticleNon-Homologous End Joining
Animation published in DNA Repair: Helleday T, Lo J, van Gent DC, Engelward BP. DNA double-strand break repair: From mechanistic understanding to cancer treatment. DNA Repair. (14 Mar 2007)
View ArticleDouble-Strand Break Repair via Single Strand Annealing
Animation published in DNA Repair: Helleday T, Lo J, van Gent DC, Engelward BP. DNA double-strand break repair: From mechanistic understanding to cancer treatment. DNA Repair. (14 Mar 2007)
View ArticleFork Collapse Repair via Homologous Recombination
This animation is part of a review: Helleday T, Lo J, van Gent DC, Engelward BP. DNA double-strand break repair: From mechanistic understanding to cancer treatment. DNA Repair. (14 Mar 2007)
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CometChip: Microarray for DNA Damage
For decades, researchers have measured DNA damage using the single cell gel electrophoresis assay, or comet assay. Originally developed by Singh et al in 1988, the basis for the assay is that damaged...
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Overview
DNA damage is known to drive mutations and cell toxicity, both of which promote cancer and aging. Recent results also suggest that DNA damage may modulate disease progression following infection....
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